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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Transplacental carcinogenesis ： ウィキペディア英語版 Transplacental carcinogenesis Transplacental carcinogenesis is a series of genotypic and/or phenotypic changes in the cells of a fetus due to ''in utero'' exposure to carcinogens. Specifically, these changes are identified as malignant by virtue of their metastatic potential. ==Transplacental transfer== The link between a pregnant mother and the fetus is such that “at all sites of direct cell-to-cell contact, maternal tissues (decidua and blood) are juxtaposed to extraembryonic cells (trophoblast).” According to Cunningham, "after conception, a biomolecular communication system is established between the fetus and mother that is operative from before the time of nidation and continues through and beyond the time of parturition."〔 This communication system is essential to all facets of the pregnancy. "Physiological processes such as fetal nutrition and fetal development progress directly from embryonic/fetal tissue-directed modifications of maternal responses."〔 Notably, the placenta is the principal site of transfer between mother and fetus. A fetus is exposed via the placenta to all substances which are present in the peripheral circulation of the mother. Overall, the abundance of toxins contained within cigarette smoke that is inhaled by the mother exerts a direct impact by altering the placental and fetal cell proliferation and differentiation. The vital balance of cellular activity is disrupted. "The association of in utero exposure to such carcinogens and the subsequent development of cancer has been reported for all childhood cancers combined and particularly for childhood acute lymphoblastic leukemia, lymphoma, and brain tumors." 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Transplacental carcinogenesis」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.